Technology

Bibliography

The following references are only a portion of the work we have published on the use of bioengineered Listeria as a therapeutic cancer vaccine vector.

Original papers (peer reviewed):
Schafer, R., Portnoy, D. A., Brassell, S. A. and Y. Paterson. Induction of a cellular immune response to a foreign antigen by a recombinant Listeria monocytogenes vaccine. J. Immunol. 149:53 - 59. 1992.
Ikonomidis, G., Paterson, Y., Kos, F. J., and D. A. Portnoy. Delivery of a viral antigen to the class I processing and presentation pathway by Listeria monocytogenes. J. Exp. Med. 180:2209 - 2218. 1994
Pan, Z-K, Ikonomidis, G., Lazenby, A., Pardoll, D., and Y. Paterson. A recombinant Listeria monocytogenes vaccine expressing a model tumour antigen protects mice against lethal tumour challenge and causes regression of established tumours. Nature Medicine 1:471-477. 1995
Sutherland, R.M., Brassell, S., Liu, Q., and Y. Paterson. The self antigen heme evades immune recognition by sequestration in some hemoproteins. Eur. J. Immunol. 25: 1810-1814. 1995
Frankel, F. R., Hegde, S., Lieberman, J., and Y. Paterson. Induction of a cell-mediated immune response to HIV gag using Listeria monocytogenes as a live vaccine vector. J. Immunol. 155: 4766 - 4774. 1995
Pan, Z-K, Ikonomidis, G., Pardoll, D., and Y. Paterson. Regression of established tumors in mice mediated by the oral administration of a recombinant Listeria monocytogenes vaccine. Cancer Research 55: 4776 - 4779. 1995
Chunduru, S., Sutherland, R.M., Stewart, G., Doms, R. and Y. Paterson . Exploitation of V8.2 T cell?receptor gene in amelioration of experimental allergic encephalomyelitis using a vaccinia virus vector. J. Immunol. 156:4940-4945. 1996
Ikonomidis, G., Portnoy, D.A., Gerhard, W. and Y. Paterson Influenza-specific immunity induced by recombinant Listeria monocytogenes vaccines. Vaccine, 15:433-440. 1997
Mata, M. and Y. Paterson, Th1 T cell responses to HIV-1 Gag protein delivered by a Listeria monocytogenes vaccine are similar to those induced by endogenous listerial antigens. J. Immunol. 163:1449 - 1456. 1999
Pan, Z.-K., Weiskirch, L. M. and Y. Paterson, Regression of established B16F10 melanoma with a recombinant Listeria monocytogenes vaccine. Cancer Research, 59:5264-5269, 1999
Beatty, G. and Y. Paterson, Interferon-gamma promotes tumor evasion of the immune system by down regulating the expression of an endogenous tumor antigen in vivo. J. Immunol., 165: 5502-5508, 2000
Mata, M., Yao, Z., Zubair, A., Syres, K. and Y. Paterson, Evaluation of a recombinant Listeria monocytogenes expressing an HIV protein that protects mice against viral challenge. Vaccine.19:1435-45, 2001
Weiskirch, L. M., Pan, Z.-K., and Y. Paterson The tumor recall response of anti-tumor immunity primed by a live, recombinant L. monocytogenes vaccine is comprised of multiple effector mechanisms. Clin. Immunol. 98: 346 - 357, 2001
Argyris, E. G., Vanderkooi, J.M., and Y. Paterson, Mutagenesis of key residues identifies the connection subdomain of HIV-1 RT as the site of inhibition by heme. Eur. J. Biochem. 268:925-931, 2001
Beatty, G. and Y. Paterson, IFN-gamma dependent inhibition of tumor angiogenesis by tumor infiltrating CD4+ T cells requires tumor responsiveness to IFN-gamma. J. Immunol. 166:2276-2282, 2001
Gerard, C.M., Baudson, N., Kraem,er, K., Bruck, C., Garcon, N., and Y. Paterson, Therapeutic potential of protein and adjuvant vaccinations on tumour growth. Vaccine,19:2583-2589, 2001
Gunn, G.R., Zubair, A., Peters, C.H., Pan, Z.-K., Wu, T.-C. and Y. Paterson, Two L. monocytogenes vaccine vectors that express different molecular forms of HPV-16 E7 induce qualitatively different T cell immunity that correlates with their ability to induce regression of established tumors immortalized by HPV-16. J. Immunol. 167:6471-6479, 2001
Lamikanra, A., Pan, Z-K., Isaacs, S., Wu T.-C., and Y. Paterson. Regression of established Human Papillomavirus (HPV-16) immortalized tumors in vivo by vaccinia viruses expressing different forms of HPV-16 E7 correlates with enhanced CD8+ T cell responses that home to the tumor site. J. Virol. 75:9654-9664, 2001
Peters, C. and Y. Paterson. Enhancing the immunogenicity of bioengineered Listeria monocytogenes by passaging through live animal hosts. Vaccine. 21:1187-94. 2003
Salzman, N.H., Chou, M.M., de Jong, H., Liu, L., Porter, E.M., and Y. Paterson. Enteric Salmonella infection inhibits paneth cell antimicrobial. peptide expression. Infection and Immunity. 71: 1109-1115. 2003
Salzman, N.H., Ghosh, D., Huttner, K., Paterson, Y., and C. L. Bevins. Human Defensin-5 (HD5) Gene in Transgenjic Mice: Paneth cell expression and protection from lethal Salmonella typhimurium infection. Nature. 422:522-526. 2003
Peters, C., Xiaohui Peng, Douven D., Zhen-Kun Pan and Y. Paterson. The induction of HIV-Gag specific CD8+ T cells in the spleen and GALT by parenteral or mucosal immunization using recombinant Listeria monocytogenes-HIV-Gag.. J. Immunol 170:5176-5187. 2003
Sewell, D.A., Douven, D., Pan, Z.-K., Rodriguez, A. and Y. Paterson. Regression of HPV-positive tumors treated with a new Listeria monocytogenes vaccine. Archives in Otorhinolaryngology.130:92-97. 2004
Neeson, P. and Y. Paterson. A new multi-parameter flow cytometric assay for monitoring lymphoma growth and spread in a pre-clinical murine model for human lymphoma. Cytometry. 60A: 8-20. 2004
Kwak, H. , Mustafa, W., Speirs, K., Abdool,A.J., Paterson, Y. and and S. Isaacs Improved protection conferred by vaccination with a recombinant vaccinia virus that incorporates a foreign antigen into the extracellular enveloped virion Virology. 332:337-348. 2004
Peng, X., Hussain, S. F. and Y. Paterson. The ability of two Listeria monocytogenes vaccines targeting Human Papillomavirus-16 E7 to induce an anti-tumor response correlates with myeloid dendritic cell function. J. Immunol. 172:6030-6038. 2004
Hussain S. F. and Y. Paterson. CD4+CD25+ Suppressor T cells that secrete inhibitory cytokines TGF- eta and IL-10 are?preferentially induced by a vaccine vector. Journal of Immunotherapy 27:339-346. 2004
Verch, T. Pan, Z.-K. and Y. Paterson A Listeria based antibiotic resistance gene-free antigen delivery system applicable to other bacterial vectors and DNA vaccines. Infection and Immunity. 72:6418-6425. 2004
Sewell, D.A., Shahabi, V., Gunn, G.R., Pan, Z.-K., Dominiecki, M.E. and Y. Paterson. Recombinant Listeria vaccines containing PEST sequences are potent immune adjuvants for the tumor associated antigen HPV-16 E7. Cancer Research. 64:8821 - 8825. 2004
Boyer, J. D., Robinson, T. M., Maciag, P. C., Peng, X., Johnson, R. S., Pavlakis, G., Lewis, M. G., Shen, A., Siliciano, R., Brown, C. R., Weiner, D., and Y. Paterson. DNA prime Listeria boost induces a cellular immune response to SIV antigens in the Rhesus Macaque model that is capable of limited suppression of SIV239 viral replication. Virology. 333: 88-101, 2005
Dominiecki, M.E., Beatty, G.L., Neeson, P Pan, Z.-K. and Y. Paterson. Tumor sensitivity to IFN- is? required for antigen-specific immunotherapy of tumors expressing human papillomavirus type 16 E7 oncoprotein. Cancer Immunol. Immunother. 54: 477-488. 2005
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